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dc.contributor.authorAltinok-Yipel, Fulya
dc.contributor.authorTekeli, İbrahim Ozan
dc.contributor.authorÖzsoy, Şule Yurdagül
dc.contributor.authorGüvenç, Mehmet
dc.contributor.authorSayın, Selin
dc.contributor.authorYipel, Mustafa
dc.date.accessioned2020-05-24T15:31:54Z
dc.date.available2020-05-24T15:31:54Z
dc.date.issued2020
dc.identifier.citationAltinok-Yipel, F., Tekeli, I. O., Ozsoy, S. Y., Guvenc, M., Sayin, S., & Yipel, M. (2019). Investigation of hepatoprotective effect of some algae species on carbon tetrachloride-induced liver injury in rats. Archives of physiology and biochemistry, 1–5. Advance online publication. https://doi.org/10.1080/13813455.2019.1702062en_US
dc.identifier.issn1381-3455
dc.identifier.issn1744-4160
dc.identifier.urihttps://doi.org/10.1080/13813455.2019.1702062
dc.identifier.urihttps://hdl.handle.net/20.500.12508/1150
dc.descriptionTekeli, İbrahim Ozan -- 0000-0002-6845-2279en_US
dc.descriptionWOS: 000503535000001en_US
dc.descriptionPubMed ID: 31855071en_US
dc.description.abstractThe aim of this study was to investigate hepatoprotective effect of some algae species such as Spirulina platensis, Chlorella vulgaris, Laminaria japonica, Sargassum sp. on experimental acute hepatotoxicity model that induced with carbon tetrachloride (CCl4) in rats. Algaes at a dose of 200 mg/kg and Silymarin at a dose of 25 mg/kg were orally administered for 7 days followed by CCl4 at a single dose (0.5 ml/kg), at the 8th day to cause experimental acute hepatotoxicity. Levels of biochemical (AST, ALT etc.), lipid peroxidation (MDA), antioxidant (GSH, CAT, GPx) parameters and histopathological examination were carried out to investigate the hepatoprotective effects of algae. In Sp group ALT and ALP levels were significantly decreased compared with CCl4 (p < .05). Histological liver structures of Sp group were similar to the control group. MDA, GPx and CAT levels of Sp and La groups were significantly different compared with CCl4 (p < .05). Based on these results, algae species able to minimise the toxic effects of CCl4 and especially S. platensis could be used in the purpose of protection against chemical-induced hepatotoxicity.en_US
dc.description.sponsorshipScientific Research Projects Coordination of Mustafa Kemal University [:14660]en_US
dc.description.sponsorshipThis work was financially supported by Scientific Research Projects Coordination of Mustafa Kemal University (Project no:14660).en_US
dc.language.isoengen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.isversionof10.1080/13813455.2019.1702062en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlgaeen_US
dc.subjectHepatoprotective effecten_US
dc.subjectCarbon tetrachlorideen_US
dc.subjectOxidative stressen_US
dc.subject.classificationBiochemistry & Molecular Biologyen_US
dc.subject.classificationBiophysicsen_US
dc.subject.classificationEndocrinology & Metabolismen_US
dc.subject.classificationPhysiologyen_US
dc.subject.classificationSpirulina | Phycocyanin | Light intensityen_US
dc.subject.otherArthrospira-platensisen_US
dc.subject.otherSpirulina-platensisen_US
dc.subject.otherChlorellaen_US
dc.subject.otherToxicityen_US
dc.subject.otherExtracten_US
dc.subject.otherProteinen_US
dc.subject.otherDamageen_US
dc.titleInvestigation of hepatoprotective effect of some algae species on carbon tetrachloride-induced liver injury in ratsen_US
dc.typearticleen_US
dc.relation.journalArchives Of Physiology And Biochemistryen_US
dc.contributor.departmentDeniz Bilimleri ve Teknolojisi Fakültesi -- Deniz Teknolojileri Bölümüen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.isteauthorSayın, Selinen_US
dc.relation.indexWeb of Science Core Collection - Science Citation Index Expandeden_US


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