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dc.contributor.authorMedetalibeyoğlu, Hilal
dc.contributor.authorKotan, Gül
dc.contributor.authorAtar, Necip
dc.contributor.authorYola, Mehmet Lütfi
dc.date.accessioned2020-11-25T10:12:07Z
dc.date.available2020-11-25T10:12:07Z
dc.date.issued2020en_US
dc.identifier.citationMedetalibeyoglu, H., Kotan, G., Atar, N., & Yola, M. L. (2020). A novel and ultrasensitive sandwich-type electrochemical immunosensor based on delaminated MXene@AuNPs as signal amplification for prostate specific antigen (PSA) detection and immunosensor validation. Talanta, 220(1), 121403. https://doi.org/10.1016/j.talanta.2020.121403en_US
dc.identifier.urihttps://doi.org/10.1016/j.talanta.2020.121403
dc.identifier.urihttps://hdl.handle.net/20.500.12508/1394
dc.description.abstractIn this study, an ultra-sensitive electrochemical immunosensor for PSA detection was designed. Firstly, gold nanoparticles (AuNPs)/p-aminothiophenol (ATP) functionalized graphene oxide (GO) composite (AuNPs- ATPGO) was constructed and modified to glassy carbon electrode (AuNPs-ATPGO/GCE). AuNPs-ATPGO/GCE was utilized as immunosensor platform to increase the amount of PSA antibody1 (Ab1). After that, self- assembled delaminated MXene-gold nanoparticles (d-Ti3C2TX MXene@AuNPs) was used to label PSA seconder antibody2 (Ab2) as signal amplification. The prepared AuNPs-ATPGO, d-Ti3C2TX MXene@AuNPs and electro-chemical immunosensor was charecterized by electrochemical impedance spectroscopy (EIS), cyclic voltam-metry (CV), scanning electron microscope (SEM), x-ray diffraction (XRD) method, x-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), fourier transform infrared spectroscopy (FTIR). The linearity range and detection limit (LOD) were obtained as 0.01–1.0 pg mL-1 and 3.0 fg mL-1, respectively.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectProstate-specific antigen (PSA)en_US
dc.subjectGold nanoparticles/graphene oxide compositeen_US
dc.subjectd-Ti3C2TX MXene@AuNPsen_US
dc.subjectImmunosensoren_US
dc.subjectValidationen_US
dc.subject.classificationChemistry
dc.subject.classificationAnalytical
dc.subject.classificationTitanium Carbide | Sodium-ion Batteries | Ion Storage
dc.subject.otherNanoparticles
dc.subject.otherComposites
dc.subject.otherCatalysis
dc.subject.otherCarbon
dc.subject.otherSensor
dc.subject.otherAntigens
dc.subject.otherCyclic voltammetry
dc.subject.otherFiber optic sensors
dc.subject.otherFourier transform infrared spectroscopy
dc.subject.otherGlass membrane electrodes
dc.subject.otherGold nanoparticles
dc.subject.otherGraphene
dc.subject.otherHigh resolution transmission electron microscopy
dc.subject.otherImmunosensors
dc.subject.otherMetal nanoparticles
dc.subject.otherScanning electron microscopy
dc.subject.otherX ray photoelectron spectroscopy
dc.subject.otherDetection limits
dc.subject.otherElectrochemical immunosensors
dc.subject.otherFunctionalized graphene
dc.subject.otherGlassy carbon electrodes
dc.subject.otherLinearity range
dc.subject.otherSignal amplifications
dc.subject.otherUltra sensitives
dc.subject.otherElectrochemical impedance spectroscopy
dc.titleA novel and ultrasensitive sandwich-type electrochemical immunosensor based on delaminated MXene@AuNPs as signal amplification for prostate specific antigen (PSA) detection and immunosensor validationen_US
dc.typearticleen_US
dc.relation.journalTalantaen_US
dc.contributor.departmentMühendislik ve Doğa Bilimleri Fakültesi -- Biyomedikal Mühendisliği Bölümüen_US
dc.identifier.volume220en_US
dc.identifier.issue1en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.isteauthorYola, Mehmet Lütfi
dc.relation.indexWeb of Science - Scopus - PubMeden_US
dc.relation.indexWeb of Science Core Collection - Science Citation Index Expanded


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