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dc.contributor.authorVeziroğlu, Salih
dc.contributor.authorAyna, Mustafa
dc.contributor.authorKohlhaas, Theresa
dc.contributor.authorSayın, Selin
dc.contributor.authorFiutowski, Jacek
dc.contributor.authorMishra, Yogendra Kumar
dc.contributor.authorKarayürek, Fatih
dc.contributor.authorNaujokat, Hendrik
dc.contributor.authorSaygılı, Eyüp İlker
dc.contributor.authorAçil, Yahya
dc.contributor.authorWiltfang, Joerg
dc.contributor.authorFaupel, Franz
dc.contributor.authorAktaş, Oral Cenk
dc.contributor.authorGülses, Aydın
dc.date.accessioned2021-06-11T07:43:47Z
dc.date.available2021-06-11T07:43:47Z
dc.date.issued2021en_US
dc.identifier.citationVeziroglu, S., Ayna, M., Kohlhaas, T., Sayin, S., Fiutowski, J., Mishra, Y. K., Karayürek, F., Naujokat, H., Saygili, E. I., Açil, Y., Wiltfang, J., Faupel, F., Aktas, O. C., & Gülses, A. (2021). Marine Algae Incorporated Polylactide Acid Patch: Novel Candidate for Targeting Osteosarcoma Cells without Impairing the Osteoblastic Proliferation. Polymers, 13(6), art. no, 847. https://doi.org/10.3390/polym13060847en_US
dc.identifier.urihttps://doi.org/10.3390/polym13060847
dc.identifier.urihttps://hdl.handle.net/20.500.12508/1752
dc.description.abstractBiodegradable collagen-based materials have been preferred as scaffolds and grafts for diverse clinical applications in density and orthopedy. Besides the advantages of using such bio-originated materials, the use of collagen matrices increases the risk of infection transmission through the cells or the tissues of the graft/scaffold. In addition, such collagen-based solutions are not counted as economically feasible approaches due to their high production cost. In recent years, incorporation of marine algae in synthetic polymers has been considered as an alternative method for preparation grafts/scaffolds since they represent abundant and cheap source of potential biopolymers. Current work aims to propose a novel composite patch prepared by blending Sargassum vulgare powders (SVP) to polylactide (PLA) as an alternative to the porcine-derived membranes. SVP-PLA composite patches were produced by using a modified solvent casting method. Following detailed material characterization to assess the cytocompatibility, human osteoblasts (HOBs) and osteosarcoma cells (SaOS-2) were seeded on neat PLA and SVP-PLA patches. MTT and BrdU assays indicated a greater cytocompatibility and higher proliferation for HOBs cultured on SVP-PLA composite than for those cultured on neat PLA. SaOS-2 cells cultured on SVP-PLA exhibited a significant decrease in cell proliferation. The composite patch described herein exhibits an antiproliferative effect against SaOS-2 cells without impairing HOBs' adhesion and proliferation.en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.isversionof10.3390/polym13060847en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectComposite patchen_US
dc.subjectMarine algaeen_US
dc.subjectOsteoblasten_US
dc.subjectSarcomaen_US
dc.subjectSargassum vulgareen_US
dc.subject.classificationPolymer Science
dc.subject.classificationButylene Glycol Adipic Acid Polyester
dc.subject.classificationPoly(Lactide)
dc.subject.classificationBionole
dc.subject.otherSulfated polysaccharide
dc.subject.otherIn-vitro
dc.subject.otherPla
dc.subject.otherScaffolds
dc.subject.otherBone
dc.subject.otherAnticoagulant
dc.subject.otherComposites
dc.subject.otherVivo
dc.subject.otherAlgae
dc.subject.otherBlending
dc.subject.otherCell proliferation
dc.subject.otherCollagen
dc.subject.otherComposite membranes
dc.subject.otherCosts
dc.subject.otherCytology
dc.subject.otherPolyesters
dc.subject.otherStress intensity factors
dc.subject.otherAntiproliferative effect
dc.subject.otherClinical application
dc.subject.otherInfection transmission
dc.subject.otherMaterial characterizations
dc.subject.otherOsteosarcoma cells
dc.subject.otherSargassum vulgare
dc.subject.otherSolvent casting method
dc.subject.otherSynthetic polymers
dc.titleMarine Algae Incorporated Polylactide Acid Patch: Novel Candidate for Targeting Osteosarcoma Cells without Impairing the Osteoblastic Proliferationen_US
dc.typearticleen_US
dc.relation.journalPolymersen_US
dc.contributor.departmentDeniz Bilimleri ve Teknolojisi Fakültesi -- Deniz Teknolojileri Bölümüen_US
dc.identifier.volume13en_US
dc.identifier.issue6en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.isteauthorSayın, Selin
dc.relation.indexWeb of Science - Scopus - PubMeden_US
dc.relation.indexWeb of Science Core Collection - Science Citation Index Expanded


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