dc.contributor.author | Deveci, Hacı Ahmet | |
dc.contributor.author | Nur, Gökhan | |
dc.contributor.author | Kükürt, Abdulsamed | |
dc.contributor.author | Kuru, Mushap | |
dc.contributor.author | Deveci, Ayla | |
dc.date.accessioned | 2023-12-11T11:49:13Z | |
dc.date.available | 2023-12-11T11:49:13Z | |
dc.date.issued | 2023 | en_US |
dc.identifier.citation | Deveci, H.A., Nur, G., Kükürt, A., Kuru, M., Deveci, A. (2023). The protective effect of caffeic acid phenethyl ester on cadmium-induced liver toxicity: A histopathological and biochemical study. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 70(4), 367-374. https://doi.org/10.33988/auvfd.1068527 | en_US |
dc.identifier.issn | 1300-0861 | |
dc.identifier.uri | https://doi.org/10.33988/auvfd.1068527 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12508/2624 | |
dc.description.abstract | In this study, the changes caused by caffeic acid phenethyl ester (CAPE) in the histopathological and biochemical parameters in the oxidant / antioxidant balance in mice with experimental cadmium toxicity were investigated. A total of 40 female Swiss albino mice were used, with 10 mice in each group. The mice were divided into four groups (Group I - Control group, Group II - CAPE group, Group III - Cadmium group, Group IV - Cadmium + CAPE group). Plasma paraoxonase (PON) activity, high-density lipoprotein (HDL), low-density lipoprotein (LDL), total sialic acid (TSA), total antioxidant capacity (TAC), total oxidant capacity (TOC), and oxidative stress index (OSI) were analyzed on mice’s blood samples. The results showed that cadmium intoxication triggered oxidative stress in the mice. It also lowered their PON activity alongside TAC and HDL levels (P<0.001, P<0.01, and P<0.01, respectively) and increased their TSA, LDL, TOC, and OSI levels (P<0.05, P<0.01, P<0.01, and P<0.01, respectively). The histopathological examination of the liver tissues revealed focal apoptotic regions, sinusoidal occlusion, and irregularity in the cadmium group and no significant change in the other groups. These results indicated that CAPE can significantly prevent biochemical and histopathological changes due to cadmium damage. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Ankara University | en_US |
dc.relation.isversionof | 10.33988/auvfd.1068527 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Cadmium | en_US |
dc.subject | Caffeic acid phenethyl ester | en_US |
dc.subject | Oxidant-antioxidant balance | en_US |
dc.subject | Paraoxonase activity | en_US |
dc.subject | Sialic acid | en_US |
dc.subject.classification | Cadmium Chlorides | |
dc.subject.classification | Oxidative Stress | |
dc.subject.classification | Testes | |
dc.subject.classification | Veterinary Sciences | |
dc.subject.other | Aryldialkylphosphatase | |
dc.subject.other | Caffeic acid phenethyl ester | |
dc.subject.other | High density lipoprotein | |
dc.subject.other | Low density lipoprotein | |
dc.subject.other | Sialic acid | |
dc.subject.other | Animal experiment | |
dc.subject.other | Animal model | |
dc.subject.other | Animal tissue | |
dc.subject.other | Antioxidant activity | |
dc.subject.other | Apoptosis | |
dc.subject.other | Biochemical analysis | |
dc.subject.other | Cadmium poisoning | |
dc.subject.other | Controlled study | |
dc.subject.other | Degeneration | |
dc.subject.other | Enzymatic hydrolysis | |
dc.subject.other | Female | |
dc.subject.other | Histopathology | |
dc.subject.other | Liver cell | |
dc.subject.other | Liver protection | |
dc.subject.other | Liver tissue | |
dc.subject.other | Liver toxicity | |
dc.subject.other | Mouse | |
dc.subject.other | Nonhuman | |
dc.subject.other | Oxidative stress | |
dc.subject.other | Tissue section | |
dc.title | The protective effect of caffeic acid phenethyl ester on cadmium-induced liver toxicity: A histopathological and biochemical study | en_US |
dc.type | article | en_US |
dc.relation.journal | Ankara Universitesi Veteriner Fakultesi Dergisi | en_US |
dc.contributor.department | Mühendislik ve Doğa Bilimleri Fakültesi -- Biyomedikal Mühendisliği Bölümü | en_US |
dc.identifier.volume | 70 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 367 | en_US |
dc.identifier.endpage | 374 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.contributor.isteauthor | Nur, Gökhan | |
dc.relation.index | Web of Science - Scopus | en_US |
dc.relation.index | Web of Science Core Collection - Science Citation Index Expanded | |