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dc.contributor.authorYola, Mehmet Lütfi
dc.contributor.authorAtar, Necip
dc.date.accessioned12.07.201910:50:10
dc.date.accessioned2019-07-12T22:05:55Z
dc.date.available12.07.201910:50:10
dc.date.available2019-07-12T22:05:55Z
dc.date.issued2019
dc.identifier.citationYola, M.L., Atar, N. (2019). Development of cardiac troponin-I biosensor based on boron nitride quantum dots including molecularly imprinted polymer. Biosensors and Bioelectronics, 126, pp. 418-424. https://doi.org/10.1016/j.bios.2018.11.016
dc.identifier.issn0956-5663
dc.identifier.issn1873-4235
dc.identifier.urihttps://doi.org/10.1016/j.bios.2018.11.016
dc.identifier.urihttps://hdl.handle.net/20.500.12508/583
dc.descriptionWOS: 000457659500053en_US
dc.description30471567en_US
dc.description.abstractThe cardiac Troponin-I (cTnI) is one of the subunits of cardiac troponin complexes and a pivotal biochemical marker of acute myocardial infarction (AMI). Due to its myocardial specificity, cTnI is widely used for the diagnosis of AMI diseases. In this study, a novel imprinted biosensor approach based on boron nitride quantum dots (BNQDs) was presented for cTnI detection in plasma samples. Various characterization methods such as scanning electron microscope (SEM), transmission electron microscope (TEM), x-ray diffraction (XRD), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were used for all characterizations of nanomaterials. After the characterization analysis, cTnI imprinted electrode was developed in the presence of 100.0 mM pyrrole containing 25.0 mM cTnI. After that, the analytical studies of cTnI in plasma samples were performed by using cTnI imprinted biosensor. The results of the study have revealed that 0.01-5.00 ng mL(-1) and 0.0005 ng mL(-1) were found as the linearity range and the detection limit (LOD). Moreover, the selectivity of cTnI imprinted glassy carbon electrode (GCE) was investigated for plasma sample analysis in the presence of other nonspecific and specific proteins including cardiac myoglobin (MYG), bovine serum albumin (BSA) and cardiac troponin T (cTnT), respectively. Furthermore, the prepared biosensor was examined in terms of stability, repeatability, reproducibility and reusability. Finally, the imprinted biosensor was applied to the plasma samples having high recovery.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.bios.2018.11.016en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMolecular imprinted biosensoren_US
dc.subjectCardiac Troponin-Ien_US
dc.subjectBoron nitride quantum dotsen_US
dc.subjectPlasmaen_US
dc.subject.classificationBiophysics
dc.subject.classificationBiotechnology & Applied Microbiology
dc.subject.classificationChemistry
dc.subject.classificationAnalytical
dc.subject.classificationElectrochemistry
dc.subject.classificationNanoscience & Nanotechnology
dc.subject.classificationMyoglobin | Troponin I | Immunosensors
dc.subject.otherFree electrochemical immunosensor
dc.subject.otherGlassy-carbon electrode
dc.subject.otherGold nanoparticles
dc.subject.otherMyocardial injury
dc.subject.otherGraphene oxide
dc.subject.otherHeart-failure
dc.subject.otherNanosheets
dc.subject.otherNanotubes
dc.subject.otherMarkers
dc.subject.otherBiochemistry
dc.subject.otherBiosensors
dc.subject.otherBody fluids
dc.subject.otherCyclic voltammetry
dc.subject.otherDiagnosis
dc.subject.otherDrug products
dc.subject.otherElectrochemical impedance spectroscopy
dc.subject.otherGlass membrane electrodes
dc.subject.otherHeart
dc.subject.otherIII-V semiconductors
dc.subject.otherMammals
dc.subject.otherNanocrystals
dc.subject.otherNitrides
dc.subject.otherPlasmas
dc.subject.otherReusability
dc.subject.otherScanning electron microscopy
dc.subject.otherTransmission electron microscopy
dc.subject.otherAcute myocardial infarction
dc.subject.otherBiochemical markers
dc.subject.otherBovine serum albumins
dc.subject.otherCharacterization methods
dc.subject.otherGlassy carbon electrodes
dc.subject.otherMolecular imprinted biosensors
dc.subject.otherSemiconductor quantum dots
dc.subject.otherBovine serum albumin
dc.subject.otherMyoglobin
dc.subject.otherPyrrole
dc.subject.otherTroponin T
dc.subject.otherUnclassified drug
dc.subject.otherBoron derivative
dc.subject.otherCarbon
dc.subject.otherControlled study
dc.subject.otherGlassy carbon electrode
dc.subject.otherHuman
dc.subject.otherImpedance spectroscopy
dc.subject.otherLimit of detection
dc.subject.otherMeasurement repeatability
dc.subject.otherProtein blood level
dc.subject.otherReproducibility
dc.subject.otherScanning electron microscopy
dc.subject.otherTransmission electron microscopy
dc.subject.otherX ray diffraction
dc.subject.otherChemistry
dc.subject.otherGenetic procedures
dc.subject.otherImpedance spectroscopy
dc.subject.otherIsolation and purification
dc.subject.otherMolecular imprinting
dc.subject.otherBiosensing techniques
dc.subject.otherBoron compounds
dc.subject.otherDielectric spectroscopy
dc.subject.otherLimit of detection
dc.subject.otherMolecular imprinting
dc.subject.otherPolymers
dc.titleDevelopment of cardiac troponin-I biosensor based on boron nitride quantum dots including molecularly imprinted polymeren_US
dc.typearticleen_US
dc.relation.journalBiosensors and Bioelectronicsen_US
dc.contributor.departmentMühendislik ve Doğa Bilimleri Fakültesi -- Biyomedikal Mühendisliği Bölümüen_US
dc.identifier.volume126en_US
dc.identifier.startpage418en_US
dc.identifier.endpage424en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.isteauthorYola, Mehmet Lütfi
dc.relation.indexWeb of Science - Scopus - PubMeden_US
dc.relation.indexWeb of Science Core Collection - Science Citation Index Expanded


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